I have suddenly been finding quite a bit of spam in my moderation queue. In the past, I'd find something in there only very rarely and only one thing at a time. I just deleted five spams in my comment moderation queue!
Also, on the new dashboard, the incoming links are pretty much nothing but spam and have been ever since the changes. In the past, the incoming links were always legitimate incoming links.
There was nothing different or unusual about the spam in the moderation queue such that Akismet might not have recognized it-- it was all gambling/casino spam.